منابع مشابه
microRNAs in Cardiovascular Diseases
microRNAs [miRNAs] are well-known, potent regulators of gene expression. There has been a much late concern the role of miRNAs in the many disease (Figure 1). Countless pathways that are impressed by miRNA regulation, for examples lipid metabolism, glucose homeostasis, endothelial cell function, are highly involved in heart disease and, many cardiac miRNAs are determinable in circulation early ...
متن کاملMicroRNAs and Cardiovascular Diseases
Coronary artery diseases (CAD) and heart failure have high mortality rate in the world, although much progress has been made in this field in last two decades. There is still a clinical need for a novel diagnostic approach and a therapeutic strategy to decrease the incidence of CAD. MicroRNAs (miRNAs) are highly conserved noncoding small RNA molecules that regulate a large fraction of the genom...
متن کاملCirculating microRNAs in Cardiovascular Diseases.
Cardiovascular Diseases (CD) are currently one of the most common causes of death. Because heart related deaths occur on such an enormous scale this phenomenon is referred to as an epidemic. Chronic and acute injury of the heart could be an effect of cardiac remodeling, which is a result of molecular, cellular and interstitial changes, influenced by hemodynamic load or neurohormonal activation ...
متن کاملMicroRNAs Expression Profiles in Cardiovascular Diseases
The current search for new markers of cardiovascular diseases (CVDs) is explained by the high morbidity and mortality still observed in developed and developing countries due to cardiovascular events. Recently, microRNAs (miRNAs or miRs) have emerged as potential new biomarkers and are small sequences of RNAs that regulate gene expression at posttranscriptional level by inhibiting translation o...
متن کاملEmerging role of microRNAs in cardiovascular diseases.
Despite the recent progress in the diagnosis and treatment of cardiovascular diseases, these are still a major source of morbidity and mortality worldwide. For this reason, a large research effort was directed to the identification of the underlying pathophysiological aspects of cardiovascular diseases. Nevertheless, many mechanisms still need to be more deeply investigated, limiting the develo...
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ژورنال
عنوان ژورنال: Journal of the American College of Cardiology
سال: 2014
ISSN: 0735-1097
DOI: 10.1016/j.jacc.2014.01.050